In an open-label clinical trial (N=217) of a single course of therapy with Accutane for severe recalcitrant nodular acne, bone density measurements at several skeletal sites were not significantly decreased (lumbar spine change >-4% and total hip change >-5%) or were increased in the majority of patients. One patient had a decrease in lumbar spine bone mineral density >4% based on unadjusted data. Sixteen (%) patients had decreases in lumbar spine bone mineral density >4%, and all the other patients (92%) did not have significant decreases or had increases (adjusted for body mass index). Nine patients (%) had a decrease in total hip bone mineral density >5% based on unadjusted data. Twenty-one (%) patients had decreases in total hip bone mineral density >5%, and all the other patients (89%) did not have significant decreases or had increases (adjusted for body mass index). Follow-up studies performed in 8 of the patients with decreased bone mineral density for up to 11 months thereafter demonstrated increasing bone density in 5 patients at the lumbar spine, while the other 3 patients had lumbar spine bone density measurements below baseline values. Total hip bone mineral densities remained below baseline (range –% to –%) in 5 of 8 patients (%).
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I work for alternative doctors in the Houston TX area and we treat with bioidentical hormones. We find so many women in particular whose hormone production has been interfered with because of birth control pills, tubal ligation, hysterectomy or uterine ablation as well as the environmental factors that put estrogen into male and female bodies and throw them out of balance. We have found people of all ages by the tens of thousands with low hormone levels because either the glands were not functioning properly or had been altered.
Many people’s hormones, such as thyroid, have never been at adequate levels for them to be healthy.
The majority of women’s progesterone levels decline by age 35 because our ovaries have aged and this is the type imbalance that causes all female problems all the way to the cancers.
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