Haloperidol dosing

The following medicines may interact with co-careldopa:

  • Monoamine oxidase (MAO) non-selective inhibitors used to treat depression such as isocarboxazid or phenelzine. These must not be used within 2 weeks of stopping treatment with co-careldopa.
  • Ferrous sulphate (iron) used to treat anaemia
  • Medicines used to lower blood pressure, such as ACE inhibitors (. captopril and enalapril), beta blockers (. atenolol and propranolol), calcium-channel blockers (. amlodipine, felodipine and nifedipine), methyldopa and moxonidine
  • Antacids used to treat indigestion
  • Benzodiazepines used to treat sleeping troubles and anxiety, such as diazepam, nitrazepam and temazepam
  • Dexamfetamine and other amphetamines used to treat narcolepsy, a condition where you keep falling asleep
  • General anaesthetics such as halothane
  • Isoniazid used to treat tuberculosis
  • Medicines known as antipsychotics used to treat mental illness such as amisulpride, chlorpromazine, haloperidol and flupentixol
  • Metoclopramide used to treat nausea, vomiting, digestion problems and migraine.
  • Moclobemide, a reversible MAO A inhibitor used to treat depression
  • Other medicines used to treat Parkinson’s disease such as anticholinergics (. orphenadrine, procyclidine), dopamine agonists (. lisuride, pergolide), selegiline (a MAO B inhibitor) and COMT inhibitors (. entacapone) or if you are already taking levodopa
  • Phenytoin used to treat epilepsy

3 to 12 years and 15 to 40 kg:
-Initial dose: mg/day orally in 2 to 3 divided doses
-Maintenance dose: to mg/kg/day

Comments:
-The daily dose may be increased every 5 to 7 days in mg increments.
-There is little evidence that behavior improvement is further enhanced by doses greater than 6 mg/day.
-Limitation of use: Treatment should be reserved for patients with severe behavior problems and/or hyperactive children only after failure to respond to psychotherapy or medications (other than antipsychotics).

Uses:
-Treatment of severe behavior problems in children, including combative, explosive hyperexcitability not accounted for by immediate provocation
-Short-term treatment of hyperactive children with excessive motor activity and accompanying conduct disorder with impulsivity, difficulty sustaining attention, aggressiveness, mood lability, and/or poor frustration tolerance.

CNS depression potentiated with alcohol, other CNS depressants. Possible neurotoxicity with lithium: monitor, discontinue if occurs. Caution with drugs that prolong the QT interval (eg, ketoconazole, paroxetine). May be potentiated by CYP3A4 inhibitors/substrates or CYP2D6 enzymes (eg, itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, promethazine. May be antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine); monitor and adjust doses. May increase intraocular pressure with anticholinergics. Monitor anticoagulants.

Patients with renal failure have poor outcomes after cardiopulmonary resuscitation (CPR). In one study of 74 patients receiving dialysis who underwent CPR for cardiopulmonary arrest, only 8 percent survived to hospital discharge, and only 3 percent were alive six months after CPR. 29 These outcomes were significantly worse than those in patients who were not receiving dialysis (12 percent survival to hospital discharge, 9 percent survival six months after CPR). Patients who survive CPR often have neurologic compromise or need ongoing mechanical ventilation.

Haloperidol dosing

haloperidol dosing

Patients with renal failure have poor outcomes after cardiopulmonary resuscitation (CPR). In one study of 74 patients receiving dialysis who underwent CPR for cardiopulmonary arrest, only 8 percent survived to hospital discharge, and only 3 percent were alive six months after CPR. 29 These outcomes were significantly worse than those in patients who were not receiving dialysis (12 percent survival to hospital discharge, 9 percent survival six months after CPR). Patients who survive CPR often have neurologic compromise or need ongoing mechanical ventilation.

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