It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking fluphenazine . It will probably take several weeks to see big enough changes in your symptoms to decide if fluphenazine is the right medication for you. If you take the fluphenazine long-acting injection, it will take a few days before fluphenazine is fully absorbed and at an adequate level to begin treating your symptoms. After starting fluphenazine long-acting injection for the first time, or re-starting after a time of no medication, your provider may also have you take fluphenazine tablets for a few days.
Promethazine is classified under FDA pregnancy risk category C. Because there are no adequate studies in pregnant women, promethazine should be considered during pregnancy only when the benefits of therapy outweigh the risks to the fetus. Guidance regarding the use of promethazine during labor and obstetric delivery is varied. According to its manufacturers, promethazine may be used alone or as an adjunct to narcotic analgesics during labor. Limited data suggest that its use is not associated with any appreciable effect on the duration of labor or delivery and does not increase the risk or need for intervention in the newborn; the effect on later growth and development of the newborn is unknown. The effects of promethazine on respiration in the exposed neonate are unclear. Although respiratory depression was observed in a study including a small group of patients, data from three large studies demonstrated no such effect. In addition, investigators in a separate study concluded that promethazine should be avoided during labor due to transient behavioral and electroencephalographic changes (persisting for < 3 days) observed in exposed newborns. Promethazine administered to a pregnant woman within 2 weeks of delivery may inhibit platelet aggregation in the newborn. Although the clinical significance of this is unknown, neonatal impairment is comparable to disorders associated with a definite bleeding state. Finally, diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
Fluphenazine came into use in 1959.  The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system .  It is available as a generic medication .  In the United States the tablets costs between and USD per day for a typical dose.  The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014.  It was discontinued in Australia around mid 2017.