Estrogenic side effects with this type of AAS are not necessary to mention, since it does not convert to estrogen. Therefore, the formation of gynecomastia, water retention and fat wrapping are not occurrence flaws. Androgenic side effects occur but to a much greater extent. It has profound effects on the scalp, which often causes hair loss, but not least relatively strong and extensive acne on the scalp, which often tends to grow to painful and scar-leaving ulcers. Also often mentioned is prostate enlargement. Noted is also slightly elevated blood pressure. It reduces the production of testosterone, like all anabolic androgenic steroids, it belongs among those with only a mild effect in this regard. Theoretically, it has a very strong potential to stimulate aggression, because it somehow negatively affects the central nervous system, but this is rather showing in women, in men it remains questionable. In long-term use, often observed are sleep disorders. Although it was used as a support drug for the treatment of cholesterol levels, in the long-term abuse decrease in HDL (good) and increase in LDL (bad) be monitored.
Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder.